Its a response to Craig Boone, a companion in Fallout: New Vegas who often reference his dead wife.
God i fucking hate you Boone. All you talk about is your dead wife. Listen Boone it's been 10 years, I know it hurts but pick up a hobby, move to freeside and marry someone local. You have a stable job working as a town guardsman and a damn good one at that. But all you do I bitch about your dead wife. Even after we complete your personal quest you still complain. For the love of God talk about something else. That's why I kill you ever play through, so I can re unite you with your wife and end your suffering